Endocrine Abstracts

Diabetes Mellitus (DM) is the ninth leading cause of death worldwide. Mortality from DM is largely attributed to disease complications. Glycemic control of DM patients reduces mortality. Studies indicated that the lack of glycemic control in DM patients could be influenced by the genetic background of the patients. Evidence suggests that adiponectin levels are dysregulated in DM patients with poor glycemic control. Serum adiponectin level is a heritable trait influenced by sin...

Background: Type two Diabetes Mellitus (T2DM) is a rapidly growing crisis. Data from several T2DM cohorts demonstrate that elevated levels of serum branched chain amino acids (BCAAs) increase the risk of the disease. BCAAs levels correlate with parameters that reflect glycemic control. Elevated levels of BCAAs in T2DM is associated with a higher risk of complications. Vitamin D plays an important role in regulating insulin action on target tissues. Normalization of serum vitam...

Background: Prostate cancer is the second leading cause of cancer-related deaths in men worldwide. A marker of poor survival in prostate cancer patients is the loss of the tumor suppressor gene PTEN (phosphoinositide-3-phosphatase). Deletion of PTEN occurs in approximately 40% of prostate cancer patients, and is associated with early biochemical recurrence, metastatic potential, and androgen-independence. Androgen-deprivation-therapy (ADT) remains the princip...